Monday, January 01, 1990

Bipolar : Imaging: Neuropsychological disturbances and cerebral blood flow in bipolar disorder.

Entrez PubMed: "Assessments included the Positive and Negative Symptom Scale, Global Assessment Functioning, Wechsler Adult Intelligence Scale (WAIS), Wisconsin Card Sorting Test (WCST), Stroop test, Trail Making Test (TMT), California Verbal Learning Test (CVLT), Wechsler Memory Scale (WMS) and phonetic verbal fluency/controlled oral word association tests. Single photon emission computed tomography (SPECT) was carried out with the administration of 99mTc-HMPAO. . . Several corrected correlations between neuropsychological function and cerebral blood flow (CBF) were identified: executive function (WCST) and striatal, frontal, temporal, cerebellum, parietal and cingulate CBF; memory (WMS, WAIS-Digits) and striatal, frontal, temporal and parietal CBF; attentional tasks (Stroop) and striatal, temporo-medial and parietal CBF; verbal learning (CVLT) and frontal, posterior temporal, cingulate and occipital CBF; psychomotor disturbances (TMT) and anterior temporal CBF; poorer intelligence performance scores (WAIS-Vocabulary) and cerebellum and parietal CBF. This study confirms the presence of functional disturbances in fronto-subcortical structures, the cerebellum and limbic system in bipolar patients."

Neuropsychological disturbances and cerebral blood flow in bipolar disorder.
Benabarre A, Vieta E, Martinez-Aran A, Garcia-Garcia M, Martin F, Lomena F, Torrent C, Sanchez-Moreno J, Colom F, Reinares M, Brugue E, Valdes M.
Aust N Z J Psychiatry. 2005 Apr;39(4):227-34.
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