Schizophrenia: Optimized voxel-based morphometry of gray matter volume in first-episode, antipsychotic-naive schizophrenia.

Entrez PubMed: "This study examined gray matter (GM) volume abnormalities in first-episode, antipsychotic-naive Indian schizophrenia patients. Magnetic resonance images of 18 schizophrenia patients and 18 matched healthy comparison subjects were analyzed by optimized voxel-based morphometry. Schizophrenia patients had significantly smaller global GM and greater global CSF volumes and smaller regional GM volume in superior frontal, inferior frontal, cingulate, post-central, superior temporal and parahippocampal gyri, inferior parietal lobule, insula, caudate nuclei, thalamus and cerebellum. Findings suggest limbic, heteromodal cortical, striatal, thalamic and cerebellar abnormalities in schizophrenia."

Optimized voxel-based morphometry of gray matter volume in first-episode, antipsychotic-naive schizophrenia.
Jayakumar PN, Venkatasubramanian G, Gangadhar BN, Janakiramaiah N, Keshavan MS.
Prog Neuropsychopharmacol Biol Psychiatry. 2005 May;29(4):587-91. Epub 2005 Apr 13.