Wednesday, February 28, 1990

Smaller Hippocampal Volume Predicts Pathologic Vulnerability to Psychological Trauma.

David Baldwin's Trauma Information, Articles:
Gilbertson, Shenton, Ciszewski, Kasai, Lasko, Orr & Pitman (2002)

Smaller Hippocampal Volume Predicts Pathologic Vulnerability to Psychological Trauma.

Originally published in: Nature Neuroscience, 2002, 5(11), 1242-1247.

In this case control study of monozygotic twins discordant for trauma exposure, Mark Gilbertson and six colleagues investigate important questions about size of hippocampus and vulnerability to trauma. The authors found that severe PTSD twin pairs -- both trauma-exposed and unexposed -- had significantly smaller hippocampi. Their results indicate that pre-existing hippocampal volume constitutes an independent risk factor for development of trauma-related psychopathology, and show one way that individual differences in vulnerability for PTSD (given a traumatic exposure) may appear. About 50 references. "
© The content of this blog is intended for personal or educational use. All rights reserved.